• Coordinating research in the area of nutrition, diet, health and physical activity

    Coordinating research in the area of nutrition,
    diet, health and physical activity

    The Joint Programming Initiative a Healthy Diet for a Healthy Life (JPI HDHL)
    brings together 26 countries that align research programming and fund new research
    to prevent or minimise diet-related chronic diseases

ERA-HDHL (2021)
“Addressing adverse and beneficial effects of food ingredients and food processing on hypersensitivities to food (FOOD_HYPERSENS)”
April 8th, 2021
Full proposals
"Standardised measurement, monitoring and/or biomarkers to study food intake, physical activity and health (STAMIFY)"
March 31st, 2021
CirculAting Bile Acids as biomarkers of metabolic health - Linking microbiotA, Diet and Health

WHAT: Bile acids (BA) through TGR5 and FXR regulate mammalian inflammation, lipid, glucose, and energy metabolism, and are in turn regulated by diet: microbe interactions in the gut. CABALA_DIET&HEALTH aims to establish circulating BA profiles as biomarkers of health, modulated by diet which reflect a change in metabolic health.

WHO: Partner (Coordinator): Kieran Tuohy, Fondazione Edmund Mach, Italy. Partner: Gianfagna Francesco, Università degli Studi dell'Insubria, Italy. Partner: Susan Joyce, University College Cork, Ireland. Partner: Julie Lovegrove, University of Reading, UK. Collaborator: Iris Shai, Ben-Gurion University of the Negev, Israel.

HOW: Using existing data and new mechanistic studies we will provide direct evidence in humans that diet: gut microbiota interactions modulate plasma BA profiles and modulate host health. Our aim is to identify plasma BA profiles as health biomarkers and establish microbiota modulation of BA signalling as a unifying molecular basis for efficacious probiotic, prebiotic and polyphenol functional foods.

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