WHAT: Bile acids (BA) through TGR5 and FXR regulate mammalian inflammation, lipid, glucose, and energy metabolism, and are in turn regulated by diet: microbe interactions in the gut. CABALA_DIET&HEALTH aims to establish circulating BA profiles as biomarkers of health, modulated by diet which reflect a change in metabolic health.
WHO: Partner (Coordinator): Kieran Tuohy, Fondazione Edmund Mach, Italy. Partner: Gianfagna Francesco, Università degli Studi dell'Insubria, Italy. Partner: Susan Joyce, University College Cork, Ireland. Partner: Julie Lovegrove, University of Reading, UK. Collaborator: Iris Shai, Ben-Gurion University of the Negev, Israel.
HOW: Using existing data and new mechanistic studies we will provide direct evidence in humans that diet: gut microbiota interactions modulate plasma BA profiles and modulate host health. Our aim is to identify plasma BA profiles as health biomarkers and establish microbiota modulation of BA signalling as a unifying molecular basis for efficacious probiotic, prebiotic and polyphenol functional foods.