WHAT: FAME aims to a) identify novel lipidomics biomarkers as biomarkers of fatty acid status and of future cardiometabolic clinical events, b) establish relationships between whole diets and specific foods with tissue status of fatty acids as explanatory factors for diet relationships with cardiometabolic health, and c) to investigate genetic determinants of fatty acid status and metabolism which modify the physiological effects of dietary intake.
WHO: Prof. Matthias Schulze, German Institute of Human Nutrition, Germany(coordinator) Prof. José López-Miranda, University of Cordoba, Spain Prof. Miguel Ángel Martínez González, University of Navarra, Spain Prof. Julie Lovegrove, University of Reading, UK Prof. Anne Marie Minihane, University of East Anglia, UK
HOW: Lipid metabolites as novel biomarkers will be identified in prospective studies on type 2 diabetes. Potential for dietary modification will be tested in controlled trials. Specific FAs and novel lipid metabolites will be tested as biomarkers of dairy fat intake and as markers of cardiometabolic health. Polyphenols and candidate genes as determinants of response to FA intake will be evaluated in the trials and cohorts.