• Coordinating research in the area of nutrition, diet, health and physical activity

    Coordinating research in the area of nutrition,
    diet, health and physical activity

    The Joint Programming Initiative a Healthy Diet for a Healthy Life (JPI HDHL)
    brings together 20 countries that align research programming and fund new research
    to prevent or minimise diet-related chronic diseases

Diet x gut microbiome-based metabotypes to determine cardiometabolic risk and tailor intervention strategies for improved health

WHAT: The human gut microbiota has been linked with incidence and progression of non-communicable diseases and their risk factors. Moreover, diet has been identified as an important modulator of microbiota composition and function, but responses vary between individuals. The underlying mechanisms of diet - microbiota interactions remain to be elucidated to provide a foundation for tailored dietary strategies for personalized precision nutrition. The aim of the DiGuMet project is to investigate how gut microbiota interact with diet and to identify the role of these interactions on cardiometabolic risk factors.

HOW: In this project the underlying mechanisms will be further dissected through extensive metabotyping using metagenomics and metabolomics combined with lifestyle data in a free-living prospective cohort subset. The hypothesis is that gut microbiota - diet interactions are a major determinant of the metabotypes and that distinct metabotypes could be reflected by predictive biomarkers. These biomarkers could then be used to tailor personalised dietary interventions to improve the molecular phenotypes among subjects at elevated risk of cardio vascular diseases. The hypothesis will be tested by conducting a dietary intervention rich in fermentable vs non-fermentable cereal fibres among subjects with signs of metabolic syndrome with distinct differences in their pattern of microbiota and microbiota-derived metabolites.

WHO: The DiGuMet consortium consists of three funded partners and two collaborators, coordinated by Prof. Rikard Landberg of Chalmers University of Technology (Sweden) email contact: rikard.landberg@chalmers.se

The other consortium partners are Cristina Andres-Lacueva, University of Barcelona (Spain) and Gabriele Riccardi, Federico II University (Italy). The Danish Cancer Society (Denmark) and Barilla G. e R. Filli (Italy) are collaborating in this project.

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