A precision nutri-epigenetic approach to tackle the mother-to-child transmission of impaired glucose metabolism
The prevalence of co-morbidities associated with adult diabetes (T2D) continues rising.
Pounding evidence has established that the risk for impaired glycaemic health starts at conception and builds-up from one generation to another. PREcisE’s overarching goal studies life-course data from the pre-conceptual period up until adulthood to explore the life-course and molecular pathways pertaining the mother to offspring transmissibility of impaired glycaemic health. PREcisE will aim at breakthrough in understanding i) the causal epigenetic pathways underpinning fetal exposure to impaired glycaemic health, ii) the role played by the glycaemic and the inflammatory load of the diet in inducing and modulating DNA methylation and iii) the life-course consequences.
PREcisE consortium is multidisciplinary, uniting epigenetic researchers, nutrition scientists, clinical scientists, biostatisticians, bioinformaticians and epidemiologists from 5 countries (UK, France, Germany, Spain and the Netherlands).
Project coordinator: Prof. Marjo-Riitta Jarvelin.
PREcisE consortium will organise its working plan into three work packages to i) perform epigenome wide association study on glucose level exposure in utero followed by downstream analysis in a biobank of liver, skeletal muscles and adipose tissues, ii) infer the primary role of pre- and postnatal dietary exposures in modulating the association of methylation with adiposity and glycaemic health outcomes and iii) integrate its findings further into a life-course model for adiposity and glycaemic health outcomes trained in large birth cohort data.