• Coordinating research in the area of nutrition, diet, health and physical activity

    Coordinating research in the area of nutrition,
    diet, health and physical activity


    The Joint Programming Initiative a Healthy Diet for a Healthy Life (JPI HDHL)
    brings together 20 countries that align research programming and fund new research
    to prevent or minimise diet-related chronic diseases

OPEN CALLS 2021
ERA-HDHL (2021)
“Addressing adverse and beneficial effects of food ingredients and food processing on hypersensitivities to food (FOOD_HYPERSENS)”
STATUS
 
Evaluation full proposals ongoing
HDHL-INTIMIC (2021)
"Standardised measurement, monitoring and/or biomarkers to study food intake, physical activity and health (STAMIFY)"
 
Evaluation pre-proposals ongoing

A precision nutri-epigenetic approach to tackle the mother-to-child transmission of impaired glucose metabolism

 

WHAT

The prevalence of co-morbidities associated with adult diabetes (T2D) continues rising.

Pounding evidence has established that the risk for impaired glycaemic health starts at conception and builds-up from one generation to another. PREcisE’s overarching goal studies life-course data from the pre-conceptual period up until adulthood to explore the life-course and molecular pathways pertaining the mother to offspring transmissibility of impaired glycaemic health. PREcisE will aim at breakthrough in understanding i) the causal epigenetic pathways underpinning fetal exposure to impaired glycaemic health, ii) the role played by the glycaemic and the inflammatory load of the diet in inducing and modulating DNA methylation and iii) the life-course consequences.

 

WHO

PREcisE consortium is multidisciplinary, uniting epigenetic researchers, nutrition scientists, clinical scientists, biostatisticians, bioinformaticians and epidemiologists from 5 countries (UK, France, Germany, Spain and the Netherlands).

Project coordinator: Prof. Marjo-Riitta Jarvelin.

HOW

PREcisE consortium will organise its working plan into three work packages to i) perform epigenome wide association study on glucose level exposure in utero followed by downstream analysis in a biobank of liver, skeletal muscles and adipose tissues, ii) infer the primary role of pre- and postnatal dietary exposures in modulating the association of methylation with adiposity and glycaemic health outcomes and iii) integrate its findings further into a life-course model for adiposity and glycaemic health outcomes trained in large birth cohort data.

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