TAGging dietary Fiber intake and their interest for health by measuring biomarkers related to the gut microbiota
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1. Overall project description
The FiberTAG project will establish a set of biomarkers linking dietary fiber (DF) intake and gut-microbiota related health effect. We aim at refining the concept of DF based on novel biological effects that can occur upon gut microbiota-nutrients interaction by using existing cohorts and by developing innovative approaches to evaluate the health interest of novel insoluble DF.
The FiberTAG consortium gathers 4 academic principal investigators from Belgium, France, Germany and Canada, respectively. They gather complementary research expertises such as 1) host physiology with emphasis on management of cardio-metabolic disorders, 2) intervention studies based on diet and prebiotic DF, 3) microbial ecology, 4) data integration and modelling. Two industrial partners (Kitozyme and Mondelez) will develop and provide selected insoluble fiber for the intervention studies.
Specific metabolites selected as biomarkers of microbiota-driven fermentation and gut-related functions will be analyzed in 5 existing cohorts of healthy or overweight populations in which the fecal microbiota composition and DF intake have been (or will be) analyzed. New intervention studies will be performed in healthy and cardiometabolic risk volunteers to evaluate the interest for health of two insoluble fibers (chitin-glucan and a wheat bran fraction).
Main outputs to be disseminated:
A repertoire and a food questionnaire for evaluation of DF intake taking into account their crucial role on key physiological parameters related to cardiometabolic risk and on health status
Innovative approaches to evaluate in intervention studies the health interest of novel insoluble DF, prone to interact with the gut microbiota
A set of novel innovative and non-invasive biomarkers linking DF intake and gut microbiota related health effect interesting to consider in the context of cardiometabolic risks
Chitin-glucan fiber : effects on the human intestinal microbiota, on the function and intestinal permeability through the selection of biomarkers of interest ; this will maybe allow to generate new health claims related to the investigated fibers (formulations: innovative administration forms)
Wheat bran: effects on the human intestinal microbiota, health interest, so as to promote the inclusion of wheat bran in products.
4.1 List of publications
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4.2 Presentation of the project
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|Scientists, Nutrition experts||.Delzenne. Microbiota in NAFLD: is there room for innovative treatments? 40th ESPEN Congress on Clinical Nutrition & Metabolism. September, 2018||Presentation|
4.3 List of submitted patents and other outputs
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