Diet-induced Arrangement of the gut Microbiome for improvement of Cardiometabolic health

JPI HDHL “Intestinal Microbiomics” (IM2015)
Diet-induced Arrangement of the gut Microbiome for improvement of Cardiometabolic health
Thomas Clavel & Dirk Haller
RWTH Aachen & TUM


Partner Organization Partner Country
University College CorkIreland
Université d'AuvergneFrance
University of Naples Federico IIItaly
Amsterdam Diabetes Center AMC-VUmcThe Netherlands
University of CopenhagenDenmark
King's College HospitalUnited Kingdom

1. Overall project description

1.1 Summary

The DINAMIC project investigates the interplay between diet, the gut microbiota, and the host in the context of cardiometabolic health. Using state-of-the-art prospective human cohorts, microbiota profiling allows the consortium to identify specific features associated with disease states. Clinical trials based on dietary interventions and fecal microbiota transplantation were designed and are being performed to test causal roles and targeted manipulations of the microbiome under controlled conditions. Mechanistic interactions within the microbiome are further investigated in vitro using continuous culture systems. Meta-omics technologies are employed, aiming at the harmonization or results and the establishment of models towards prediction of detrimental and favourable gut environments with respect to cardiometabolic health. Hence, the expected impact of DINAMIC is to bring light into diet-microbiome interactions for improvement of metabolic conditions, which will contribute to the establishment of appropriate dietary recommendations.

1.2 Highlights

4. Impact

4.1 List of publications

AuthorsTitleYear, Issue, PPPartners NumberDoiPdf

4.2 Presentation of the project

Target groupAuthorsMeans of communicationHyperlinkPdf

4.3 List of submitted patents and other outputs

Patent licencePartners involvedYearInternational eu or national patentCommentPdf

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This project has received funding from the European Union’s
H2020 Research and Innovation Programme under grant agreement n.696300

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