Increasing evidence suggests that several non-communicable diseases, including obesity and its associated
metabolic disorders, are inherited from parents to offspring over several generations by non-genetic mechanisms.
In this context, it has been suggested that parental environmental cues might induce epigenetic modifications in
the germ line, which are transmitted to the progeny. Hence, etiological and risk factors that contribute to the
insurgence of non-communicable diseases have the potential to drive the development of pathology(ies) in the
This work will contribute to a better understanding of the molecular mechanisms involved in the non-genetic
inheritance of obesity in human, and to the identification of obese-susceptibility loci whose expression can be
modulated by environmental factors and consequently induce the development of the disease in successive