Impact of MEditerranean Diet, Inflammation and Microbiome on plaque vulnerability and microvascular dysfunction after an Acute Coronary Syndrome. A randomized, controlled, mechanistic clinical trial.
|Partner Organization||Partner Country|
|Tel Aviv University||Israel|
|University of Gothenburg||Sweden|
1. Overall project description
Coronary atherosclerosis is a leading cause of mortality and disability worldwide. Continuous efforts are needed to improve secondary prevention and understand the mechanism underlying disease progression. Based on primary prevention trials, a potential benefit of the Mediterranean diet after an acute coronary syndrome can be anticipated. The integrated microbiome-mediated/immunologic and metabolic pathways by which the Mediterranean diet modifies cardiovascular risk remain mostly unknown. Intestinal and oral dysbiosis is involved in the pathogenesis of atherosclerosis and microbiome dynamics may account for some of the observed benefits of Mediterranean diet.Our first objective is to evaluate the effects of a well-controlled Mediterranean diet intervention on atherosclerotic plaque vulnerability and coronary endothelial dysfunction after an episode of acute coronary syndrome. The second objective is to decipher the interplays among diet, microbiota, immunity and metabolism responsible for the observed effects. We propose a randomized mechanistic clinical trial, using state-of-the-art efficacy read-outs. The multidisciplinary consortium includes highly experienced cardiologists, nutritionists and experts in translational research in immunology, microbiomics, genomics, proteomics, metabolomics and metagenomics. This study will provide valuable insights to identify potential microbiome therapeutic targets for coronary artery disease.
The current proposal consists of original research on a diet intervention for secondary prevention in patients who have suffered acute coronary syndrome. This study will provide valuable insights to identify potential microbiome therapeutic targets for coronary artery disease.Clinical data registration, sampling and analysis are in course. Initial data will be able by June 2021. The study will be completed by May 2022.
4.1 List of publications
|Authors||Title||Year, Issue, PP||Partners Number||Doi|
|Ana I Fernández,a Javier Bermejo,a* Raquel Yotti,a Miguel Ángel Martínez-Gonzalez,b Alex Mira,c Uri Gophna,d Roger Karlsson,e Reem Al-Daccak,f Irene Martín-Demiguel,a Enrique Gutiérrez-Ibanes,a Dominique Charron,f and Francisco Fernández-Avilésa On behalf of the MEDIMACS researcher team||The impact of Mediterranean diet on coronary plaque vulnerability, microvascular function, inflammation and microbiome after an acute coronary syndrome: study protocol for the MEDIMACS randomized, controlled, mechanistic clinical trial||2021||ALL||10.21203/rs.3.rs-317853/v1||Download|
4.2 Presentation of the project
|Target group||Authors||Means of communication||Hyperlink|
|Medical doctors||Ana Isabel Fernández. Francisco Fernandez-Avilés, Javier Bermejo. Presentación del ensayo MEDIMACS. Hospital Geenral Univeresitario Gregorio Marañón. Madrid. Spain.2018-2019||40 persons|
|Cardiologists and researchers in cardiology||Irene Mendez, Ana I Fernandez, Javier Bermejo, Francisco Fernández-Aviles. Rehabilitación cardiaca-MEDIMACS. Congreso Nacional de Enfermedades Cardiológicas. Barcelona. Spain. 2019||250|
|Researchers||Javier Bermejo, Ana I Fernández, Francisco Fernández-Avilés. MEDIMACS: dieta, microbiota y aterosclerosis. Reunión Anual CIBERCV. Madrid. Spain. 2019||250|
4.3 List of submitted patents and other outputs
|Patent licence||Partners involved||Year||International eu or national patent||Comment|