Knowledge Platform on Food, Diet, Intestinal Microbiomics and Human Health
HDHL INTIMIC JFA2 “Knowledge Platform on Food, Diet, Intestinal Microbiomics and Human Health” (INTIMIC KP)
Knowledge Platform on Food, Diet, Intestinal Microbiomics and Human Health
KP Intestinal Microbiomics
2019-10-01
2022-05-31
Dr. Jildau Bouwman
Netherlands Organisation for Applied Scientific Research (TNO)
The Netherlands
Consortium
| Partner Organization | Partner Country |
|---|---|
| University of Turin | Italy |
| Instituto de Productos Lácteos de Asturias | Spain |
| Hospital Regional Universitario de Málaga-Instituto de Investigación Biomédica de Málaga | Spain |
| Wageningen University and Research | The Netherlands |
| Medical University of Vienna | Austria |
| Medical University of Graz | Austria |
| Istituto Superiore di Sanità | Italy |
| Max Delbrueck Center for Molecular Medicine | Germany |
| Flanders Research Institute for Agriculture, Fisheries and Food | Belgium |
| University of Milan, Department of Food, Environmental and Nutritional Sciences | Italy |
| University of Barcelona, Nutrition & Food Science Department | Spain |
| Sigmund Freud University Vienna | Austria |
| Faculty of Science and Technology, Free University of Bolzano | Italy |
| University of Bari Aldo Moro | Italy |
| University of Naples Federico II | Italy |
| Research Centre for Food and Nutrition, CREA (Council for Agricultural Research and Economics) | Italy |
| Alma Mater Studiorum University of Bologna | Italy |
| INRA Unité de Nutrition Humaine | France |
| Max Rubner-Institute | Germany |
| University of Veterinary Medicine Vienna, Institute for Milk Hygiene, Milk Technology and Food Science | Austria |
| Migal - Galilee Research Institute | Israel |
| Amedes genetics GmbH | Germany |
| University of Florence, NEUROFARBA Department | Italy |
| Department of Endocrinology, Diabetology and Clinical Nutrition, University of Kiel | Germany |
| University of Graz | Austria |
| Leibniz Institute for Prevention Research and Epidemiology - BIPS | Germany |
| University of Milano, Department of Pharmacological and Biomolecular Sciences | Italy |
| INRA/ University of Clermont Auvergne | France |
| Ben-Gurion University of the Negev | Israel |
| Helmholtz Zentrum München | Germany |
| University Medical Center Groningen | The Netherlands |
| Consiglio Nazionale delle Ricerche- Istituto di Fisiologia Clinica | Italy |
| The Open University of Israel | Israel |
| Netherlands Organisation for applied scientific research (TNO) | The Netherlands |
| Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg | Germany |
| Institute for Laboratory Animal Science, Hannover Medical School | Germany |
| Institute of Animal Science, University of Hohenheim | Germany |
| University of Gothenburg | Sweden |
| University of Vienna | Austria |
| Unilever Research & Development | The Netherlands |
| NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University | The Netherlands |
| Bonn University | Germany |
| INSERM-University of Rouen | France |
| Human Nutrition Research Center | France |
| Chalmers University, Division Food and Nutrition Science, Department of Biology and Biological Engineering | Sweden |
| Centre d'Immunologie et des Maladies Infectieuses | France |
| Institute of Network Biology, Helmholtz Zentrum München | Germany |
| University Clinic RWTH Aachen, Medical Clinic III | Germany |
| University of Florence, Department of Biology | Italy |
| Federico II University Dept Clinical Medicine and Surgery | Italy |
1. Overall project description
1.1 Summary
Studies suggest that the intestinal microbiome modulates the risk of several chronic diseases, including type 2 diabetes, allergy, cardiovascular disease, and colorectal cancer (CRC). Dietary factors are related to chronic disease risk, and they have been suggested to modulate the composition and function of the gut microbiome. However, detailed knowledge on the relationship of diet, the microbiome, and chronic disease risk is still limited.
The overarching aim of the knowledge platform is to foster studies on the microbiome, nutrition and health by assembling available information in the field of microbiome research in food, nutrition and health in a comprehensive way, which also includes other disciplines (e.g. food science, metabolomics) that are relevant in the context of microbiome research. The goal is to make this information findable, accessible, interoperable and reusable (FAIR) to the scientific community and to link and provide in-depth information to various stakeholders.
Through these efforts a network of transnational and multidisciplinary collaboration will emerge, that will further develop and increase the impact of microbiome research in human health. Urgent areas of research in this KP were identified to be the roles of microbiome in early infancy, during ageing and in subclinical and clinically manifest disease.
1.2 Highlights
We identified 23 observational studies on nutrition and microbiome from INTIMIC (https://pubmed.ncbi.nlm.nih.gov/34579168/) that are available for future joint analyses (use case on gut microbiome composition in obese versus non-obese including data from 8 observational studies ongoing) as well that in a systematic review on gut microbiome composition in obese versus non-obese, we found that a substantial proportion of the 32 included cross-sectional studies found lower diversity and differences in gut microbiome composition in obese versus non-obese adults, but the observed heterogeneity across studies precludes clear answers (https://pubmed.ncbi.nlm.nih.gov/35010887/).
4. Impact
4.1 List of publications
| Authors | Title | Year, Issue, PP | Partners Number | Doi | |
|---|---|---|---|---|---|
| Edoardo Pasolli, Francesca De Filippis, Italia E. Mauriello, Fabio Cumbo, Aaron M. Walsh, John Leech, Paul D. Cotter, Nicola Segata, and Danilo Ercolini | Large-scale genome-wide analysis links lactic acid bacteria from food with the gut microbiome | ||||
| González-Domínguez R, Jáuregui O, Queipo-Ortuño MI, Andres-Lacueva C, | Characterization of the human exposome by a comprehensive and quantitative large scale multi-analyte metabolomics platform. | DOI:10.1021/acs.analchem.0c02008. | |||
| Colin D Kay, Michael N Clifford, Pedro Mena, Gordon J McDougall, Cristina Andres-Lacueva, Aedin Cassidy, Daniele Del Rio, Nikolai Kuhnert, Claudine Manach, Gema Pereira-Caro, Ana Rodriguez-Mateos, Augustin Scalbert, Francisco Tomás-Barberán, Gary Williamson, David S Wishart, and Alan Crozier | Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites. | ||||
| Francesca De Filippis, Edoardo Pasolli, and Danilo Ercolini. | Newly explored Faecalibacterium diversity is connected to age, lifestyle, geography, and disease | ||||
| Silvia Bolsega*, Andre Bleich* and Marijana Basic* | Synthetic Microbiomes on the Rise—Application in Deciphering the Role of Microbes in Host Health and Disease | 10.3390/nu13114173 | |||
| Martina Reutzel, Rekha Grewal, Carsten Esselun, Sebastian Friedrich Petry, Thomas Linn, Annette Brandt, Ina Bergheim*, Gunter P. Eckert | Effects of different standard and special diets on cognition and brain mitochondrial function in mice | 10.1080/1028415X.2021.1906392 | |||
| Marianna Roselli, Fausta Natella, Paola Zinno, Barbara Guantario, Raffaella Canali, Emily Schifano, Maria De Angelis*, Olga Nikoloudaki, Marco Gobbetti*, Giuditta Perozzi and Chiara Devirgiliis* | Colonization Ability and Impact on Human Gut Microbiota of Foodborne Microbes From Traditional or Probiotic-Added Fermented Foods: A Systematic Review | 10.3389/fnut.2021.689084 | |||
| Schneider KM, Mohs A, Kilic K, Candels LS, Elfers C, Bennek E, Schneider LB, Heymann F, Gassler N, Penders J*, Trautwein C | Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis | 10.3390/ijms20020308 | |||
| Pinart M, Nimptsch K, Forslund SK, Schlicht K, Gueimonde M, Brigidi P, Turroni S, Ahrens W, Hebestreit A, Wolters M, Dötsch A, Nöthlings U, Oluwagbemigun K, Cuadrat RRC, Schulze MB, Standl M, Schloter M, De Angelis M, Iozzo P, Guzzardi MA, Vlaemynck G, Penders J, Jonkers DMAE, Stemmer M, Chiesa G, Cavalieri D, De Filippo C, Ercolini D, De Filippis F, Ribet D, Achamrah N, Tavolacci M-P, Déchelotte P, Bouwman J, Laudes M, Pischon T* | Identification and Characterization of Human Observational Studies in Nutritional Epidemiology on Gut Microbiomics for Joint Data Analysis | https://doi.org/10.3390/nu13093292 | |||
| Mariona Pinart*, Andreas Dötsch*, Kristina Schlicht*, Matthias Laudes*, Jildau Bouwman*, Sofia K. Forslund*, Tobias Pischon* and Katharina Nimptsch* | Gut microbiome composition in obese and non-obese persons: a systematic review and meta-analysis | https://doi.org/10.3390/nu14010012 | |||
| Homann C-M, Rossel CAJ, Dizzell S, Bervoets L, Simioni J, Li J, Gunn E, Surette MG, de Souza RJ, Mommers M*, Hutton EK, Morrison KM, Penders J*, van Best N, Stearns JC. | Infants’ First Solid Foods: Impact on Gut Microbiota Development in Two Intercontinental Cohorts. | https://doi.org/10.3390/nu13082639 | |||
| Geisler C, Pankoke J, Schlicht K*, Knappe C, Rohmann N, Hartmann K, Settgast U, Türk K, Seoudy AK, Franke A, Schreiber S, Schulte DM, Laudes M*. | BMI, Alcohol Consumption and Gut Microbiome Species Richness Are Related to Structural and Functional Neurological Abnormalities | 10.3390/nu13113743 | |||
| Matthias Laudes*, Corinna Geisler, Nathalie Rohmann, Jildau Bouwman*, Tobias Pischon*, Kristina Schlicht* | Microbiota in Health and Disease-Potential Clinical Applications | 10.3390/nu13113866 | |||
| Calabrese FM, Porrelli A, Vacca M, Comte B, Nimptsch K, Pinart M, Pischon T, Pujos-Guillot E, De Angelis M* | Metaproteomics Approach and Pathway Modulation in Obesity and Diabetes: A Narrative Review | https://doi.org/10.3390/nu14010047 | |||
| Borrás C*, Mas-Bargues C, Román-Domínguez A, Sanz-Ros J, Gimeno-Mallench L, Inglés M, Gambini J, Viña J | BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians | 10.3390/ijms21020418 | |||
| Mas-Bargues C, Borrás C*, Viña J | Bcl-xL as a Modulator of Senescence and Aging | 10.3390/ijms22041527 | |||
| Strasser B, Wolters M, Weyh C, Krüger K, Ticinesi A* | The Effects of Lifestyle and Diet on Gut Microbiota Composition, Inflammation and Muscle Performance in Our Aging Society | https://doi.org/10.3390/nu13062045 |
4.2 Presentation of the project
| Target group | Authors | Means of communication | Hyperlink | |
|---|---|---|---|---|
| ECIS 2020 | Maya Stemmer, Gilad Ravid, Yisrael Parmet | Oral Presentation |
4.3 List of submitted patents and other outputs
| Patent licence | Partners involved | Year | International eu or national patent | Comment |
|---|
