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results found for 'Metabolism'.
- Background and aimThe aryl hydrocarbon receptor (AhR) is a transcription factor recently shown to be crucial for the maintenance of intestinal homeostasis, however its precise gut luminal activators and functional consequences are unknown. Activators originate from (i) the diet, such as indole-3-carbinol from cruciferous vegetables, (ii) the microbiota, (iii) lactic acid bacteria, used in food or…
- Background and aimSub-optimal status of Riboflavin (vitamin-B2) may be more widespread than generally recognised because of reliance on dietary data only in many nutrition surveys and lack of reliable biomarker data. The DERiVE project aimed to address this by developing accessible riboflavin biomarkers and by demonstrating important functional, gene-nutrient and health effects of optimal…
- Background and aimBile acids (BA) through G protein-coupled bile acid receptor 1 (GPBAR1 or TGR5) and nuclear receptors like Farnesoid X receptor (FXR) regulate mammalian inflammation, and lipid, glucose, energy, and xenobiotic metabolism. The gut microbiota modulates the enterohepatic circulation of BA and microbially produced secondary BA appear to be more potent receptor agonists than primary…
- Combining vitamin E-functionalized CHOcolate with physical exercise to reduce the risK Of protein-energy malnutrition in pre-dementia AGEd people Image AbstractThe CHOKO-AGE project starts from the assumption that nutrition and physical exercise can support each other to prevent protein-energy malnutrition (PEM) and…
- Innovative plant protein fibre and physical activity solutions to address poor appetite and prevent undernutrition in older adults Image AbstractOlder adults with poor appetite are at high risk of undernutrition due to the role of appetite as key driver of food intake. Although a negative impact on health is known, there…
- Early life is fundamental for brain and microbiota development. Gut microbiota influences brain function. Maternal obesity affects maturation of gut microbiota and is an important predictor of cognitive dysfunction in the offspring. Cognitive decline through life is an increasingly invalidating condition, due to population ageing and the high frequency of predisposing factors (obesity, unhealthy…
- The main objectives of the OCTOPUS project were:to determine, in mouse models, to what extent apoA-I/HDL modulate gut microbiota composition, intestinal homeostasis/immunity, plasma metabolome and atherosclerosis development.to determine whether apoA-I/HDL levels modulate gut microbiota composition and plasma metabolome in human cohorts, and to identify possible correlations between microbiota…
- A comprehensive study of the innate immune surveillance against infection during postprandial metabolism Image AbstractPostprandial inflammation describes a systemic state of activation of immune cells following the ingestion of macronutrients from food. While this response helps fight infections, it…
