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- Cardiovascular and metabolic diseases are a primary cause of morbidity and mortality worldwide. Diet is a major risk factor for cardio-metabolic health, but is challenging to study in part because metabolic response to diet is highly individualised. Characterising the molecular pathways that mediate personalised responses to diet is critical to effectively tackle the current epidemic. Epigenetic…
- Important gaps remain in our understanding how diet and the composition of the gut microbiota influence the function of our immune system. TransMic focused on communities in sub-Saharan Africa that are in different stages of urbanization and a nutrition and epidemiologic transition. These communities offer unique opportunities to investigate the ‘diet-microbiome-health’ axis for the following…
- Coronary atherosclerosis is a leading cause of mortality and disability worldwide. Continuous efforts are needed to improve secondary prevention and understand the mechanism underlying disease progression. Based on primary prevention trials, a potential benefit of the Mediterranean diet after an acute coronary syndrome can be anticipated. The integrated microbiome-mediated/immunologic and…
- Background and aimRecent findings convincingly demonstrate that Advanced Glycation End Products (AGEs) are modifiable by diet and reflect changes in healthy state. SALIVAGES investigates whether that diet-induced AGEs can act as reliable biomarkers of changes in health status and/or risk, focusing on the most highly accessible source of AGEs, the saliva. The main objectives of SALIVAGES were the…
- The aim of Meatic project is to understand the role of the gut microbiome as determinant of the effect of diet on colorectal cancer risk and to identify specific associated microbiome profiles. We compared in humans (WP1) and experimental animals (WP2-WP3-WP4), a high-risk meat-based diet (MBD) with a pesco-vegetarian diet (PVD) associated with a lower CRC risk and a MBD diet medium risk…
- The effect of diet on immune and vaccine responses in people living with obesity in transitioning communities
- Biomarker signatures of diet, physical activity and sleep in children and youth
- The DINAMIC project investigates the interplay between diet, the gut microbiota, and the host in the context of cardiometabolic health. Using state-of-the-art prospective human cohorts, microbiota profiling allows the consortium to identify specific features associated with disease states. Clinical trials based on dietary interventions and fecal microbiota transplantation were designed and are…