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- Mitochondria represent central regulators of nutritional homeostasis and of the aging process. Epidemiological studies, including data from our cohort, indicate nutritional risk and preventive factors associated with dietary intake for the development of age-related parameters. Notably, studies from this network revealed the importance of a finely tuned mitochondria-autophagy axis as a preventive…
- Preventing obesity, sarcopenia and Sarcopenic Obesity in retirement – digital personalized interventions for healthy NUTrition and physical activity for Seniors
- Genetic predisposition and general overnutrition are discussed as key factors in the development of non-alcoholic fatty liver disease (NAFLD); however, alterations of intestinal microbiota composition and associated impairments of intestinal barrier function are thought to be critical in the onset and progression of NAFLD. Also studies suggest a pivotal role of bile acids and microbial bile acid…
- Background and aim:Studies suggest that the intestinal microbiome modulates the risk of several chronic diseases, including type 2 diabetes, allergy, cardiovascular disease, and colorectal cancer (CRC). Dietary factors are related to chronic disease risk, and they have been suggested to modulate the composition and function of the gut microbiome. However, detailed knowledge on the relationship of…
- Early life is fundamental for brain and microbiota development. Gut microbiota influences brain function. Maternal obesity affects maturation of gut microbiota and is an important predictor of cognitive dysfunction in the offspring. Cognitive decline through life is an increasingly invalidating condition, due to population ageing and the high frequency of predisposing factors (obesity, unhealthy…
- Background and aimAccording to the Developmental Origins of Health and Disease hypothesis early life exposure to environmental factors plays a critical role in defining offspring health in childhood and later life. Thus adaptation to suboptimal nutrition during pregnancy or early childhood may perpetuate intergenerational transmission of a range of adverse health outcomes. Epigenetic phenomena…
- Background and aimThe human gut microbiota is a complex ecosystem consisting of hundreds to thousands of distinct bacterial species which provide important immune, metabolic and trophic functions for their host. Our knowledge on the processes contributing to microbial dysbiosis has a direct impact on our ability to manage and maintain human health. Early childhood appears a crucial age-window…
- Background and aimThe aryl hydrocarbon receptor (AhR) is a transcription factor recently shown to be crucial for the maintenance of intestinal homeostasis, however its precise gut luminal activators and functional consequences are unknown. Activators originate from (i) the diet, such as indole-3-carbinol from cruciferous vegetables, (ii) the microbiota, (iii) lactic acid bacteria, used in food or…
