Search on HDHL
Filters
62
results found for 'Metabolism'.
- Obesity promotes Non Alcoholic Fatty Liver Diseases (NAFLD) through mechanisms involving the gut microbiota. From 2 cohorts of obese women (FLORINASH FP7), in which a multilevel omics approach was used, we identified a microbiome architecture indicating increased dietary lipids processing. This was associated with hepatic insulin signaling perturbations, a transcriptomic profile indicative of…
- Coronary atherosclerosis is a leading cause of mortality and disability worldwide. Continuous efforts are needed to improve secondary prevention and understand the mechanism underlying disease progression. Based on primary prevention trials, a potential benefit of the Mediterranean diet after an acute coronary syndrome can be anticipated. The integrated microbiome-mediated/immunologic and…
- The DINAMIC project investigates the interplay between diet, the gut microbiota, and the host in the context of cardiometabolic health. Using state-of-the-art prospective human cohorts, microbiota profiling allows the consortium to identify specific features associated with disease states. Clinical trials based on dietary interventions and fecal microbiota transplantation were designed and are…
- Background and aimHEALTHMARK investigated the complex associations between diet, microbiota, tryptophan metabolites of microbial metabolism, and metabolic health in a set-up of identification, replication, and validation of associations. The project, organized in five work packages (WP) comprised two observational and two intervention studies.In WP1, the University of Bonn (UB) using the DOrtmund…
- Background and aimIn recent decades, nutritional science and biomedicine have made enormous progress in the development of modern molecular and cellular research technologies. This has led to the awareness that health is a state of homeostasis, not only for our various eukaryotic cells, but also for the millions of living microorganisms that live in symbiosis on (e.g. skin) or in (e.g. gut) our…
