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- Background and aimHEALTHMARK investigated the complex associations between diet, microbiota, tryptophan metabolites of microbial metabolism, and metabolic health in a set-up of identification, replication, and validation of associations. The project, organized in five work packages (WP) comprised two observational and two intervention studies.In WP1, the University of Bonn (UB) using the DOrtmund…
- The physiological impact of dietary methylglyoxal Image AbstractBioactive compounds produced during food processing can have strong pro-inflammatory properties with potential health implications. Modulation of chronic inflammation may be the mechanism linking diet to the risk of chronic diseases such as diabetes and cardiovascular…
- BackgroundBacteria play a crucial role in our healthy development, and in protecting against chronic disease. The goal of EarlyVir was to find out whether the same applies for viruses and if we can isolate important viruses and use them as a technology to improve human health.Objectives:Determine the viral composition of the infant gut at age 1 yearDetermine whether it was influenced by the diet…
- Pregnancy and infancy are critical periods for nutritional programming of metabolic health. Epigenetic changes such as DNA methylation seem to have a crucial role linking early-life nutrition to metabolic health across the life course. The aim of NutriPROGRAM was to identify early-life nutrition-related factors and related epigenetic pathways leading to metabolic adaptations and disease across the…
